Variable base-word positioning in English blends

Cet article explore les conditions qui résultent du positionnement variable du terme source dans les amalgames anglais, dans lesquels les mêmes termes sources ont un ordre variable, créant ainsi deux amalgames différents, c’est-à-dire des doublets d’amalgames. Pour les doublets d’amalgames non synonymiques, tels que (egg × prégnant >) éggnant ‘pregnant with egg’ et prégegg ‘egg that counts down pregnancy’, le facteur principal est que dans les amalgames endocentriques, le terme source qui constitue la tête sémantique se place à droite. Pour les doublets d’amalgames synonymiques, tels que plúmpricot ~ ápriplum ‘plum‑apricot hybrid’ () éggnant ‘pregnant with egg’ and prégegg ‘egg that counts down pregnancy’, the main factor is that in endocentric blends, the base word that contributes the semantic head is right‑aligned. In synonymous blend doublets, such as plúmpricot ~ ápriplum ‘plum‑apricot hybrid’ (< plum × ápricot), variable base‑word positioning results from at least four factors interacting: (i) segmental faithfulness – maximizing segmental similarity; (ii) Pāṇini’s law – positioning the short base word before the long one; (iii) monosyllabic integrity – keeping the monosyllabic base word in the same syllable; and (iv) syntagmatic faithfulness – matching the linear order of the base words to their order in a would‑be syntactic constituent

Rhotics.New Data and Perspectives

This book provides an insight into the patterns of variation and change of rhotics in different languages and from a variety of perspectives. It sheds light on the phonetics, the phonology, the socio-linguistics and the acquisition of /r/-sounds in languages as diverse as Dutch, English, French, German, Greek, Hebrew, Italian, Kuikuro, Malayalam, Romanian, Slovak, Tyrolean and Washili Shingazidja thus contributing to the discussion on the unity and uniqueness of this group of sounds

Mainstreaming domestic and gender-based violence into sociology and the criminology of violence

Sociological and criminological views of domestic and gender-based violencegenerally either dismiss it as not worthy of consideration, or focus on specificgroups of offenders and victims (male youth gangs, partner violence victims). Inthis paper, we take a holistic approach to violence, extending the definition fromthat commonly in use to encompass domestic violence and sexual violence. Weoperationalize that definition by using data from the latest sweep of the CrimeSurvey for England and Wales. By so doing, we identify that violence is currentlyunder-measured and ubiquitous; that it is gendered, and that other forms of violence (family violence, acquaintance violence against women) are equally ofconcern. We argue that violence studies are an important form of activity forsociologists

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

The phonetics of Modern Hebrew rhotics

This paper investigates manner variation of Israeli Hebrew rhotics with respect to two factors: prosodic position and speaker gender. An acoustic experimental study shows that although the Hebrew rhotic phoneme tends to be a dorsal approximant, it is significantly more likely to undergo fortition in onset position. This fortition is a result of target overshoot, the rhotic subsequently being produced with a greater degree of constriction than that which would have resulted in an approximant, subsequently surfacing as a stop, a fricative, a tap or a trill. Furthermore, in onset position, female speakers show more variation and produce fewer approximants than male speakers

Postmortem diffusion MRI of the entire human spinal cord at microscopic resolution

The human spinal cord is a central nervous system structure that plays an important role in normal motor and sensory function, and can be affected by many debilitating neurologic diseases. Due to its clinical importance, the spinal cord is frequently the subject of imaging research. Common methods for visualizing spinal cord anatomy and pathology include histology and magnetic resonance imaging (MRI), both of which have unique benefits and drawbacks. Postmortem microscopic resolution MRI of fixed specimens, sometimes referred to as magnetic resonance microscopy (MRM), combines many of the benefits inherent to both techniques. However, the elongated shape of the human spinal cord, along with hardware and scan time limitations, have restricted previous microscopic resolution MRI studies (both in vivo and ex vivo) to small sections of the cord. Here we present the first MRM dataset of the entire postmortem human spinal cord. These data include 50 μm isotropic resolution anatomic image data and 100 μm isotropic resolution diffusion data, made possible by a 280 h long multi-segment acquisition and automated image segment composition. We demonstrate the use of these data for spinal cord lesion detection, automated volumetric gray matter segmentation, and quantitative spinal cord morphometry including estimates of cross sectional dimensions and gray matter fraction throughout the length of the cord. Keywords: Spinal cord, Magnetic resonance microscopy, Tractography, Human, Gray matte

Blending in English

The e-journal Lexis published its 14th issue, devoted to “Blending in English”, in December 2019. La revue électronique Lexis - revue de lexicologie anglaise a mis en ligne son numéro 14 en décembre 2019. Celui-ci est consacré à l'« amalgamation en anglais »